Yeah, I plug Pandora straight into my audio card,that's all.

Now,here are some setting I use recently a lot:
SGL>HUM 10.0
US HI-G : Gain 10.0, Bass 5.0, Middle 2.0 , Treble 9.0
JAZ 1x15 8.0
Modulation : FX OFF
PPDLY 3 5.3
PLATE 2 4.3
NR 8.3
Notice one thing,if you add per example chorus in modulation fx spot
you'll get kind of more gain cause each of effects brings more
power to output,they are all lined in serial setup.
So you might have problems with gain
if your pickups don't have enough high output
while lacking of sustain has to do with pickups and action as well,
if string action is too low then you're missing lot of sustain.
Noise Reduction also eats sustain if you set it too high
in order to kill noise caused by low-output pickups.
You mentioned mics,so you plug it into an amp?
I must say that Pandora isn't great deal
in combination with an amp.
First of all,it has one stereo output and when you plug it
into an amp with any cable (mono or stereo) you're
feeding your amp with just a half of sound from Pandora.
I suggest you to plug it straight into audio card,
using cable as I do,in 2 inputs,panned about 70% left and right.