Hybrid picking is a cross over between regular picking and finger picking. Alternately playing this technique contributes to the vibrancy and playfulness of a whole song. You need to focus on getting your pick to pluck the strings in time with your fingers, which is sometimes harder than it sounds. Pay attention to the timing, since the majority of notes occurs in counter rhythm (=syncopation).
A mixolydian scale
I use the bridge pickup, which is the best for the classic Telecaster sound. Software used for this kind of sound is Guitar Rig 5 with a factory preset: Country Twang clean.