This lick can be used in various places within a blues solo, but a good time to use it is when returning to the I chord (in this case E). Two important things regarding this lick:
1. Bend the first note one and a half steps
2. When sliding into the G# note in bar 2, use downstrokes and pick the open low E string as well at the same time. With the tip of your middle finger mute the A string while sliding, to prevent it from ringing.
For this lick, the focus is on using both major and minor pentatonic scales. The lick is mostly major scale-based, but you will find notes from the minor pentatonic and blues scales too.
I used Amplitube 3 software for this mini lick, tubescreamer and Mesa Boogie MKII emulations.
Guitar is a Fender Stratocaster, bridge humbucker single pickup.