Here's a lick that explores the sound of the C7#11 chord with the Lydian b7 mode. Often used in Jazz & Fusion, this mode is s must know tool for all jazz players!
As its name indicates, this mode is Lydian with a minor 7th. It's the 4th mode of the G melodic minor scale and contains an interesting note : the #11 (or #4).
It will work on a 7th dominant chord to add some color to your phrasing.
Use the neck pickup and cut the high freqs with the tone knob if necessary.
I use the Mesa Boogie V-Twin preamp on the clean channel connected directly to the sound card and I'm adding a little bit of reverb and compression in Pro Tools.